Method of preparing surface chemical gradients

Procédé de préparation de gradients chimiques surfaciques

Abstract

La présente invention concerne un procédé de fonctionnalisation d'un support comprenant la mise en contact d'au moins une partie de la surface dudit support comportant des fonctions aldéhydes avec une solution comprenant au moins deux composés porteurs d'une fonction aminé de pKa différents, dans lequel la zone de contact entre la surface du support et la solution varie au cours du temps et où le pH de la solution est modifié au cours de cette variation.
The present invention relates to a method of functionalizing a substrate, comprising the bringing into contact of at least a part of the surface of said substrate, comprising aldehyde functions, with a solution comprising at least two compounds bearing an amine function and having different pKas, in which the zone of contact between the surface of the substrate and the solution varies over time and where the pH of the solution is modified during this variation.

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    CN-103952143-AJuly 30, 2014中国科学院武汉物理与数学研究所Trimethyl cyanine fluorescence probe used for protein labeling and synthetic method thereof